Clinical Trial Eligibility Screener
Automated patient screening system that evaluates medical criteria to determine clinical trial eligibility based on multiple health factors.
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Solution
This eligibility screening system streamlines the clinical trial recruitment process by automating patient qualification assessment. It evaluates candidates against six key medical criteria: diagnosis type, disease stage, current medications, age, treatment history, and comorbidities. The system flags patients with qualifying diagnoses (breast, lung, or colorectal cancer) while excluding those with advanced stage IV disease.
The screening tool identifies medication conflicts that could compromise trial outcomes, particularly immunosuppressants, anticancer agents, and corticosteroids. Age verification ensures patients fall within the 18-75 year trial parameters. Treatment history analysis prevents enrollment of heavily pre-treated patients, limiting prior treatments to two or fewer. The system also screens for disqualifying comorbidities including autoimmune disorders, heart failure, and uncontrolled diabetes, providing detailed justification for each eligibility determination.
How it works
The eligibility assessment follows this process:
- Input Collection: Captures comprehensive patient data including diagnosis, disease stage, current medications, age, prior treatments, and comorbidities.
- Diagnosis Verification: Validates if the patient's condition matches targeted cancer types (breast, lung, colorectal).
- Stage Evaluation: Confirms disease progression is within acceptable parameters (stages I-III).
- Medication Screening: Identifies contraindicated medications that would exclude participation.
- Age Validation: Verifies patient age falls within protocol-defined range.
- Treatment History: Ensures limited prior therapy exposure (≤2 treatments).
- Comorbidity Assessment: Screens for exclusionary concurrent medical conditions.
- Eligibility Determination: Aggregates all criteria results to produce a final eligibility decision with detailed reasoning.
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